Background: Thrombotic microangiopathies are complex diseases, requiring early differential diagnosis and targeted intervention.
Objectives: Presentation of clinical phenotype and diagnostic algorithm, discussion of underlying pathophysiology, clinical management and therapy.
Methods: Summary of current knowledge from literature and expert opinion.
Results: Our understanding of pathophysiology and therapeutic options have changed substantially in recent years. Early differential diagnosis and targeted therapy are of prognostic relevance.
Conclusions: A better understanding of underlying pathophysiology, increased clinical awareness and novel therapeutic options allow for a better prognosis of patients with thrombotic microangiopathy.
Keywords: STEC-HUS; TTP; Thrombotic microangiopathy; aHUS.