Ginsenoside Re improves skin barrier function in HaCaT keratinocytes under normal growth conditions

Yuri Oh; Hye-Won Lim; Kyunghoon Kim; Chang-Jin Lim

doi:10.1080/09168451.2016.1206808

Ginsenoside Re improves skin barrier function in HaCaT keratinocytes under normal growth conditions

Biosci Biotechnol Biochem. 2016 Nov;80(11):2165-2167. doi: 10.1080/09168451.2016.1206808. Epub 2016 Jul 13.

Authors

Yuri Oh¹, Hye-Won Lim², Kyunghoon Kim¹, Chang-Jin Lim^{2

3}

Affiliations

¹ a Department of Biological Sciences , Kangwon National University , Chuncheon , Korea.
² b Shebah Biotech Inc. , Chuncheon , Korea.
³ c Department of Biochemistry , Kangwon National University , Chuncheon , Korea.

PMID: 27405604
DOI: 10.1080/09168451.2016.1206808

Abstract

Ginsenoside Re (Re), a major ginsenoside of ginseng, enhanced the cornified cell envelope (CE) formation in HaCaT keratinocytes under normal conditions. In HaCaT keratinocytes, Re was also able to upregulate filaggrin protein and caspase-14 activity in a concentration-dependent manner. These findings reasonably imply that Re possesses a desirable property of improving skin barrier function.

Keywords: HaCaT; caspase-14; cornified cell envelope; filaggrin; ginsenoside Re.