Abstract
Three guaiane-type sesquiterpenoids, dysodensiols G-I (1-3), together with five known sesquiterpenoids (4-8) were isolated from the stems of Fissistigma oldhamii (Hemsl.) Merr. Compound 1 represents the first example of an ene(6 → 5)-abeo-14-norguaiane sesquiterpenoid derived from natural products. Their structures were elucidated by a combination of 1D and 2D NMR and MS spectra. The absolute configuration of 2 was determined by an X-ray crystallographic analysis. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed a potent inhibitory effect on the proliferation of synoviocytes with an IC50 value of 1.0 µM.
Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
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Animals
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Annonaceae / chemistry*
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Cell Proliferation / drug effects
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Crystallography, X-Ray / methods
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Drugs, Chinese Herbal / chemistry*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy / methods
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Mass Spectrometry / methods
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Molecular Structure
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Norisoprenoids / pharmacology
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Plant Stems / chemistry
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Rats
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Rats, Sprague-Dawley
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Sesquiterpenes, Guaiane / chemistry*
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Sesquiterpenes, Guaiane / isolation & purification
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Sesquiterpenes, Guaiane / pharmacology*
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Synoviocytes / cytology
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Synoviocytes / drug effects*
Substances
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Drugs, Chinese Herbal
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Norisoprenoids
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Sesquiterpenes
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Sesquiterpenes, Guaiane
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guaiane