ESI-MS studies of the non-covalent interactions between biologically important metal ions and N-sulfonylcytosine derivatives

J Mass Spectrom. 2016 Nov;51(11):998-1005. doi: 10.1002/jms.3810.

Abstract

The aim of this report is to present the electrospray ionization mass spectrometry results of the non-covalent interaction of two biologically active ligands, N-1-(p-toluenesulfonyl)cytosine, 1-TsC, 1 and N-1-methanesulfonylcytosine, 1-MsC, 2 and their Cu(II) complexes Cu(1-TsC-N3)2 Cl2 , 3 and Cu(1-MsC-N3)2 Cl2 and 4 with biologically important cations: Na+ , K+ , Ca2+ , Mg2+ and Zn2+ . The formation of various complex metal ions was observed. The alkali metals Na+ and K+ formed clusters because of electrostatic interactions. Ca2+ and Mg2+ salts produced the tris ligand and mixed ligand complexes. The interaction of Zn2+ with 1-4 produced monometal and dimetal Zn2+ complexes as a result of the affinity of Zn2+ ions toward both O and N atoms. Copyright © 2016 John Wiley & Sons, Ltd.

Keywords: Cu(II) complexes; ESI-MS; N-1-sulfonylcytosine derivatives; metal ions Na+, K+, Ca2+, Mg2+ and Zn2+; non-covalent interactions.

MeSH terms

  • Cations / chemistry
  • Coordination Complexes / chemistry
  • Cytosine / analogs & derivatives*
  • Cytosine / chemistry*
  • Ligands
  • Metals / chemistry*
  • Nitrogen
  • Oxygen
  • Spectrometry, Mass, Electrospray Ionization
  • Static Electricity
  • Tandem Mass Spectrometry

Substances

  • Cations
  • Coordination Complexes
  • Ligands
  • Metals
  • Cytosine
  • Nitrogen
  • Oxygen