Oligomers of N-Substituted β(2)-Homoalanines: Peptoids with Backbone Chirality

Kang Ju Lee; Woo Sirl Lee; Hyosuk Yun; Yu-Jung Hyun; Chang Deok Seo; Chul Won Lee; Hyun-Suk Lim

doi:10.1021/acs.orglett.6b01726

Oligomers of N-Substituted β(2)-Homoalanines: Peptoids with Backbone Chirality

Org Lett. 2016 Aug 5;18(15):3678-81. doi: 10.1021/acs.orglett.6b01726. Epub 2016 Jul 12.

Authors

Kang Ju Lee¹, Woo Sirl Lee¹, Hyosuk Yun², Yu-Jung Hyun¹, Chang Deok Seo¹, Chul Won Lee², Hyun-Suk Lim^{1

3}

Affiliations

¹ Departments of Chemistry and Advanced Material Science, Pohang University of Science and Technology (POSTECH) , Pohang 37673, South Korea.
² Department of Chemistry, Chonnam National University , Gwangju 61186, South Korea.
³ Department of Biochemistry and Molecular Biology, Indiana University School of Medicine , Indianapolis, Indiana 46202, United States.

PMID: 27404658
DOI: 10.1021/acs.orglett.6b01726

Abstract

A new class of peptoid-based peptidomimetics composed of oligomers of N-substituted β(2)-homoalanines is reported. Design, solid-phase synthesis, and preliminary circular dichroism studies of oligomers of N-alkylated β(2)-homoalanines consisting of up to 8-mers are described.

Publication types

Research Support, Non-U.S. Gov't