Unusual glycogenic hepatopathy causing abnormal liver enzymes in a morbidly obese adolescent with well-controlled type 2 diabetes: resolved after A1c was normalized by metformin

Clin Obes. 2016 Aug;6(4):281-4. doi: 10.1111/cob.12154.

Abstract

We report, for the first time, a case of an accumulation of glycogen in the liver causing elevation of liver enzymes in a 15-year-old morbidly obese adolescent male with well-controlled type 2 diabetes. Notably, the patient did not have poorly controlled type 1 diabetes and did not require insulin. After normalization of the A1c with metformin, elevated liver enzymes returned to normal.

Keywords: Abnormal liver enzymes; Mauriac syndrome; diabetes; hepatomegaly.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Glycated Hemoglobin / metabolism*
  • Humans
  • Liver Diseases / enzymology*
  • Male
  • Metformin / administration & dosage
  • Metformin / therapeutic use*
  • Obesity, Morbid / blood
  • Obesity, Morbid / pathology*

Substances

  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
  • Metformin