MeOTf- and TBD-Mediated Carbonylation of ortho-Arylanilines with CO2 Leading to Phenanthridinones

Sheng Wang; Peng Shao; Gaixia Du; Chanjuan Xi

doi:10.1021/acs.joc.6b01318

MeOTf- and TBD-Mediated Carbonylation of ortho-Arylanilines with CO2 Leading to Phenanthridinones

J Org Chem. 2016 Aug 5;81(15):6672-6. doi: 10.1021/acs.joc.6b01318. Epub 2016 Jul 20.

Authors

Sheng Wang¹, Peng Shao¹, Gaixia Du¹, Chanjuan Xi^{1

2}

Affiliations

¹ Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
² State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.

PMID: 27398605
DOI: 10.1021/acs.joc.6b01318

Abstract

Carbonylation of o-arylanilines utilizing CO2 as a carbonyl source for the synthesis of important phenanthridinones with a free (NH)-lactam motif has been described under metal-free condition. A range of o-arylanilines were transformed to the corresponding phenanthridinones in high yields.

Publication types

Research Support, Non-U.S. Gov't