Distinct intrathecal interleukin-17/interleukin-6 activation in anti-N-methyl-d-aspartate receptor encephalitis

Jung-Ick Byun; Soon-Tae Lee; Jangsup Moon; Keun-Hwa Jung; Jun-Sang Sunwoo; Jung-Ah Lim; Tae-Joon Kim; Yong-Won Shin; Keon-Joo Lee; Jin-Sun Jun; Han Sang Lee; Woo-Jin Lee; Young-Sook Kim; Soyun Kim; Daejong Jeon; Kyung-Il Park; Ki-Young Jung; Manho Kim; Kon Chu; Sang Kun Lee

doi:10.1016/j.jneuroim.2016.05.023

Distinct intrathecal interleukin-17/interleukin-6 activation in anti-N-methyl-d-aspartate receptor encephalitis

J Neuroimmunol. 2016 Aug 15:297:141-7. doi: 10.1016/j.jneuroim.2016.05.023. Epub 2016 Jun 1.

Authors

Jung-Ick Byun¹, Soon-Tae Lee², Jangsup Moon², Keun-Hwa Jung², Jun-Sang Sunwoo³, Jung-Ah Lim², Tae-Joon Kim², Yong-Won Shin², Keon-Joo Lee², Jin-Sun Jun², Han Sang Lee², Woo-Jin Lee², Young-Sook Kim⁴, Soyun Kim⁴, Daejong Jeon⁵, Kyung-Il Park⁶, Ki-Young Jung², Manho Kim², Kon Chu⁷, Sang Kun Lee⁸

Affiliations

¹ Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
² Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
³ Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Department of Neurology, Soonchunhyang University School of Medicine, Seoul, South Korea.
⁴ Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea.
⁵ Advanced Neural Technologies, Co., Seoul, South Korea.
⁶ Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea; Department of Neurology, Seoul National University Hospita Healthcare System Gangnam Center, Seoul, South Korea.
⁷ Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: stemcell.snu@gmail.com.
⁸ Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.

PMID: 27397087
DOI: 10.1016/j.jneuroim.2016.05.023

Abstract

The aim of this study was to compare serum and cerebrospinal fluid (CSF) cytokine/chemokine levels between anti-NMDAR and anti-LGI1 encephalitis patients. Samples from fourteen anti-NMDAR encephalitis patients, ten anti-LGI1 encephalitis patients, and ten controls were analyzed for the following cytokines/chemokines: IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17A, IL-23, GM-CSF, IFN-gamma, TNF-alpha, and CXCL13. Compared with controls, CSF IL-17A, IL-6 and CXCL13 were elevated in anti-NMDAR encephalitis patients (post-hoc p-values 0.002, 0.011, and 0.011, respectively) but not in anti-LGI1 encephalitis patients. In the serum, only IL-2 was increased in anti-NMDAR encephalitis. Intrathecal IL-17/IL-6 activation is a characteristic of anti-NMDAR encephalitis.

Keywords: Autoimmune encephalitis; CXCL13; Cytokine; IL-17A; IL-6; LGI1; NMDAR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / blood
Anti-N-Methyl-D-Aspartate Receptor Encephalitis / cerebrospinal fluid*
Autoantibodies / blood
Autoantibodies / cerebrospinal fluid
Cytokines / blood
Cytokines / cerebrospinal fluid
Female
Glycoproteins / immunology
Humans
Interleukin-17 / cerebrospinal fluid*
Interleukin-6 / cerebrospinal fluid*
Male
Middle Aged
Statistics, Nonparametric
Young Adult

Substances

Autoantibodies
Cytokines
Glycoproteins
Interleukin-17
Interleukin-6