Protection induced by a commercial bivalent vaccine against Foot-and-Mouth Disease 2010 field virus from Ecuador

Vaccine. 2016 Jul 29;34(35):4140-4144. doi: 10.1016/j.vaccine.2016.06.073. Epub 2016 Jul 6.

Abstract

Foot-and-Mouth Disease serotype O circulated endemically in Ecuador for many years, with an upsurge occurring in 2009. This manuscript describes retrospectively in vitro and in vivo laboratory studies to predict the field effectiveness of a commercial FMD vaccine to protect against the field strain, and explains the key actions and epidemiological strategies followed by the country to control the disease. The results established that the use of a good quality oil vaccine, manufactured with strains that were isolated long ago: O1 Campos Br/58 and A24 Cruzeiro Br/55; combined with the correct epidemiological strategies, are useful to control field strains when used in periodic biannual vaccination campaigns.

Keywords: Disease control; Expectancy of protection; Foot-and-Mouth Disease; Vaccination; Vaccine matching.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Viral / blood
  • Capsid Proteins / genetics
  • Cattle
  • Cattle Diseases / prevention & control*
  • Cattle Diseases / virology
  • Cross Protection
  • Ecuador
  • Foot-and-Mouth Disease / prevention & control*
  • Foot-and-Mouth Disease Virus / classification
  • Vaccination / veterinary
  • Viral Vaccines / immunology
  • Viral Vaccines / therapeutic use*

Substances

  • Antibodies, Viral
  • Capsid Proteins
  • VP1 protein, Foot-and-mouth disease virus
  • Viral Vaccines