Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion

Mudit Mudit; Khalid A El Sayed

doi:10.1016/j.drudis.2016.06.032

Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion

Drug Discov Today. 2016 Nov;21(11):1745-1760. doi: 10.1016/j.drudis.2016.06.032. Epub 2016 Jul 6.

Authors

Mudit Mudit¹, Khalid A El Sayed²

Affiliations

¹ Department of Pharmaceutical, Social and Administrative Sciences, D'Youville College School of Pharmacy, Buffalo, NY 14201, USA. Electronic address: muditm@dyc.edu.
² Department of Basic Pharmaceutical Sciences, School of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71201, USA.

PMID: 27394962
DOI: 10.1016/j.drudis.2016.06.032

Abstract

The marine environment is a reliable source for the discovery of novel treatment options for numerous diseases. Past research efforts toward the discovery of marine-derived anticancer agents have resulted in several commercially available marine-based drugs. The pharmaceutical value of anticancer drugs from marine natural products (MNPs) ranges from US$563 billion to US$5.69 trillion. In this review, we highlight several marine-derived entities with the potential for cancer control and prevention through the inhibition of crucial tumor cell motility and/or migration steps involved in subsequent cancer metastases. This report also covers the major hurdles typically faced by the MNPs research scientific community.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents*
Aquatic Organisms*
Biological Products*
Cell Movement
Drug Discovery
Humans
Neoplasm Invasiveness
Neoplasms / drug therapy
Neoplasms / pathology

Substances

Antineoplastic Agents
Biological Products