Chocs anaphylactiques d'origine médicamenteuse : sous-notification et PMSI

Hadyl Asfari; Cédric Bousquet; Béatrice Trombert Paviot; Florelle Bellet; Geneviève Mounier; Fakhria Marsille; Marie-Noëlle Beyens; Claire Guy

doi:10.2515/therapie/2014057

Chocs anaphylactiques d'origine médicamenteuse : sous-notification et PMSI

Therapie. 2014 Nov-Dec;69(6):483-90. doi: 10.2515/therapie/2014057.

[Article in French]

Authors

Hadyl Asfari¹, Cédric Bousquet², Béatrice Trombert Paviot², Florelle Bellet³, Geneviève Mounier³, Fakhria Marsille³, Marie-Noëlle Beyens³, Claire Guy³

Affiliations

¹ INSERM, U1142, LIMICS, Paris, France ; Sorbonne Universités, UPMC Université Paris 6, UMRS 1142, LIMICS, Paris, France ; Université Paris 13, Sorbonne Paris Cité, LIMICS (UMRS 1142), Villetaneuse, France; Service de santé publique et d'information médicale, Centre hospitalier universitaire de Saint-Étienne - Hôpital Nord, Saint-Étienne, France. Electronic address: Hadyl.Asfari@chu-st-etienne.fr.
² INSERM, U1142, LIMICS, Paris, France ; Sorbonne Universités, UPMC Université Paris 6, UMRS 1142, LIMICS, Paris, France ; Université Paris 13, Sorbonne Paris Cité, LIMICS (UMRS 1142), Villetaneuse, France; Service de santé publique et d'information médicale, Centre hospitalier universitaire de Saint-Étienne - Hôpital Nord, Saint-Étienne, France.
³ Centre de pharmacovigilance, Centre hospitalier universitaire de Saint-Étienne, Saint-Étienne - Hôpital Nord, France.

PMID: 27392901
DOI: 10.2515/therapie/2014057

Abstract

Aim: To evaluate the value of research in the case-mix database to identify cases of drug-related anaphylactic or anaphylactoid shock.

Methods: Hospital stays of patients discharged from the University Hospital of Saint-Étienne between July 1st 2009 and June 30th 2012. Five codes from the international classification of diseases were selected: T88.6, T88.2, J39.3, T80.5 and T78.2.

Results: Among 89 cases identified by the programme for medicalization of information system (programme de médicalisation des systèmes d'information, PMSI), 40 were selected (45%). Of these, 16 cases were spontaneously reported by physicians. The unspecific code "anaphylactic shock unspecified (T78.2)" was coded for 57.5% of cases.

Conclusion: The study confirms the interest of the PMSI as a tool for health monitoring, in addition to spontaneous reporting. Nevertheless, coding with insufficient precision about the causal role of the drug, requires a return to the medical record and so an important time consuming process.

Keywords: PMSI; anaphylactic shocks; choc anaphylactique; diagnosis related group; pharmacovigilance; sous-notification; under-reporting.

Publication types

English Abstract