Lasiodiplodia species fungal osteomyelitis in a multiple myeloma patient

Transpl Infect Dis. 2016 Oct;18(5):761-764. doi: 10.1111/tid.12573. Epub 2016 Sep 9.

Abstract

Lasiodiplodia species are environmental fungi that have been reported as a cause of infection in both immunocompetent and immunocompromised patients. We present a case of fungal osteomyelitis caused by Lasiodiplodia species in a patient with multiple myeloma after autologous stem cell transplant. The patient was successfully treated with a combination of surgery and oral voriconzole. To the best of our knowledge, this is the first reported case of fungal osteomyelitis caused by Lasiodiplodia species.

Keywords: Lasiodiplodia species; fungal osteomyelitis; multiple myeloma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use
  • Amputation, Surgical
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use
  • Ascomycota / isolation & purification*
  • Biopsy
  • Blood Cell Count
  • Fatal Outcome
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunocompromised Host
  • Magnetic Resonance Imaging
  • Male
  • Multiple Myeloma / therapy*
  • Osteomyelitis / blood
  • Osteomyelitis / microbiology*
  • Osteomyelitis / pathology
  • Osteomyelitis / therapy*
  • Skin / pathology
  • Toes / pathology
  • Transplantation, Autologous / adverse effects
  • Treatment Refusal
  • Voriconazole / administration & dosage
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • liposomal amphotericin B
  • Amphotericin B
  • Voriconazole