A Short Synthesis of Aphanamol I in Both Racemic and Enantiopure Forms

Abstract

A short synthesis of the biologically active sesquiterpene natural product (+)-aphanamol I in both racemic and enantiopure forms is reported. Key steps include: a catalytic enantioselective conjugate addition, an oxidative radical cyclization, and a ring-expanding Claisen rearrangement.

Keywords: Claisen rearrangement; aphanamol; conjugate addition; radical cyclization; total synthesis.