Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole "click" ligands

J Inorg Biochem. 2016 Dec:165:92-99. doi: 10.1016/j.jinorgbio.2016.06.017. Epub 2016 Jun 15.

Abstract

Six platinum(II) complexes of the type [Pt(PL)(AL)]2+, where PL is a bidentate pyridyl-1,2,3-triazole "click" ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.

Keywords: Cell growth inhibition; Click; Platinum; Triazole; X-ray crystal structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Click Chemistry
  • Crystallography, X-Ray
  • Cytotoxins* / chemical synthesis
  • Cytotoxins* / chemistry
  • Cytotoxins* / pharmacology
  • Humans
  • MCF-7 Cells
  • Magnetic Resonance Spectroscopy
  • Organoplatinum Compounds* / chemical synthesis
  • Organoplatinum Compounds* / chemistry
  • Organoplatinum Compounds* / pharmacology
  • Triazoles / chemical synthesis
  • Triazoles / chemistry
  • Triazoles / pharmacology

Substances

  • Cytotoxins
  • Organoplatinum Compounds
  • Triazoles