2014 Jeffrey M. Hoeg Award Lecture: Transcriptional Control of Monocyte Development

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1722-33. doi: 10.1161/ATVBAHA.116.304054. Epub 2016 Jul 7.

Abstract

Monocytes and macrophages are key immune cells involved in the early progression of atherosclerosis. Transcription factors that control their development in the bone marrow are important therapeutic targets to control the numbers and functions of these cells in disease. This review highlights what is currently known about the transcription factors that are critical for monocyte development.

Keywords: atherosclerosis; bone marrow; microRNAs; monocytes; transcription factors.

Publication types

  • Lecture
  • Review

MeSH terms

  • Animals
  • Bone Marrow Cells / classification
  • Bone Marrow Cells / immunology
  • Bone Marrow Cells / physiology*
  • Cell Differentiation*
  • Cellular Microenvironment
  • Gene Expression Regulation
  • Genotype
  • Hematopoiesis, Extramedullary
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Monocytes / classification
  • Monocytes / immunology
  • Monocytes / physiology*
  • Myelopoiesis
  • Phenotype
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic*

Substances

  • MicroRNAs
  • Transcription Factors