Recurrent Arterial Thrombosis as a Presenting Feature of a Variant M3-Acute Promyelocytic Leukemia

Pranit N Chotai; Kalenda Kasangana; Abhinav B Chandra; Atul S Rao

doi:10.5758/vsi.2016.32.2.65

Recurrent Arterial Thrombosis as a Presenting Feature of a Variant M3-Acute Promyelocytic Leukemia

Vasc Specialist Int. 2016 Jun;32(2):65-71. doi: 10.5758/vsi.2016.32.2.65. Epub 2016 Jun 30.

Authors

Pranit N Chotai¹, Kalenda Kasangana², Abhinav B Chandra³, Atul S Rao²

Affiliations

¹ Division of Vascular Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, NY, USA; Division of Pediatric Surgery, Department of Surgery, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.
² Division of Vascular Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, NY, USA.
³ Division of Hematology and Oncology, Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY, USA; Division of Hematology and Oncology, Yuma Regional Cancer Center, Yuma, AZ, USA.

Abstract

Acute limb ischemia (ALI) is a common vascular emergency. Hematologic malignancies are commonly associated with derangement of normal hemostasis and thrombo-hemorrhagic symptoms during the course of the disease are common. However, ALI as an initial presenting feature of acute leukemia is rare. Due to the rarity of this presentation, there is a scarcity of prospective randomized data to optimally guide the management of these patients. Current knowledge is mainly based on isolated cases. We report our experience managing a patient who presented with ALI and was found to have occult leukemia. A review of all cases with ALI as a presenting feature of acute leukemia is also presented.

Keywords: Acute limb ischemia; Acute myeloid leukemia-M3; Acute promyelocytic leukemia; Arterial thrombosis; Cold leg.

Publication types

Case Reports