Protective effects of Emblica officinalis (Amla) on metal-induced lipid peroxidation in human erythrocytes

Pak J Pharm Sci. 2016 May;29(3 Suppl):1023-6.

Abstract

The protective potential of Emblica officinalis (amla) was investigated on metal-induced lipid per oxidation in human erythrocytes. Increases in the levels of MDA and catalase activity were assessed as lipid per oxidation. In addition, glutathione peroxidase (GPX), glutathione (GSH), and ascorbic acid levels were assessed as antioxidant indices. Preliminary investigation of the extract exhibited a significant reduction in lipid per oxidation and an increase in antioxidant abilities, such as a decrease in MDA, GPx and GSH (P<0.05). A significant reduction in erythrocyte hemolysis induced by hydrogen peroxide was observed using amla extract (P<0.05). These findings show that amla extract has significant protective potential against lipid per oxidation.

MeSH terms

  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Biomarkers / metabolism
  • Cytoprotection
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism
  • Hemolysis / drug effects
  • Humans
  • Hydrogen Peroxide / toxicity
  • Lipid Peroxidation / drug effects*
  • Metals / toxicity*
  • Oxidative Stress / drug effects*
  • Phyllanthus emblica* / chemistry
  • Phytotherapy
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plants, Medicinal

Substances

  • Antioxidants
  • Biomarkers
  • Metals
  • Plant Extracts
  • Hydrogen Peroxide