Vascular networks are formed and maintained through a multitude of angiogenic processes, such as sprouting, anastomosis and pruning. Only recently has it become possible to study the behavior of the endothelial cells that contribute to these networks at a single-cell level in vivo This Review summarizes what is known about endothelial cell behavior during developmental angiogenesis, focusing on the morphogenetic changes that these cells undergo.
Keywords: Anastomosis; Angiogenesis; Endothelial cells; Live imaging; Pruning; Sprouting; Vegf; Zebrafish.
© 2016. Published by The Company of Biologists Ltd.