Biomimetic cardiovascular stents for in vivo re-endothelialization

Chunyong Liang; Yuecheng Hu; Hongshui Wang; Dan Xia; Qiang Li; Jiao Zhang; Jianjun Yang; Baoe Li; Haipeng Li; Dong Han; Mingdong Dong

doi:10.1016/j.biomaterials.2016.06.042

Biomimetic cardiovascular stents for in vivo re-endothelialization

Biomaterials. 2016 Oct:103:170-182. doi: 10.1016/j.biomaterials.2016.06.042. Epub 2016 Jun 24.

Authors

Chunyong Liang¹, Yuecheng Hu², Hongshui Wang³, Dan Xia⁴, Qiang Li⁵, Jiao Zhang³, Jianjun Yang⁶, Baoe Li³, Haipeng Li³, Dong Han⁷, Mingdong Dong⁸

Affiliations

¹ Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China. Electronic address: liangchunyong@126.com.
² Tianjin Chest Hospital, Tianjin 300051, China.
³ Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China.
⁴ Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China; Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark.
⁵ Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark.
⁶ Institute of Modern Optics, Nankai University, Tianjin 300071, China.
⁷ National Center for Nanoscience and Technology, Beijing 100190, China.
⁸ Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark. Electronic address: dong@inano.au.dk.

PMID: 27380443
DOI: 10.1016/j.biomaterials.2016.06.042

Abstract

The use of cardiovascular stents for rapid in vivo re-endothelialization is a promising strategy for reducing cardiovascular implantation or preventing local thrombus formation and restenosis. Surface-patterned intravascular endoprosthetic stents have been developed to prevent life-threatening complications. In this study, vascular smooth muscle cell (VSMC)-biomimetic surface patterns were fabricated on 316L cardiovascular stents using a femtosecond laser and then implanted into the iliac artery of rabbit. The in vitro data revealed that the bionic surface patterns matched the morphology of the VSMCs well, which promotes the adhesion, proliferation, and migration of human umbilical vein endothelial cells. In addition, the patterned surfaces can significantly enhance re-endothelialization. Consequently, the surface biomimetic stent with the VSMC surface pattern is likely an effective approach to ensure rapid re-endothelialization and possibly reduce the incidence of in-stent restenosis.

Keywords: Biomimetic surface pattern; Cardiovascular stent; Femtosecond laser; Re-endothelialization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomimetic Materials / chemistry*
Blood Vessel Prosthesis*
Endothelium, Vascular / cytology*
Endothelium, Vascular / growth & development*
Equipment Failure Analysis
Guided Tissue Regeneration / instrumentation*
Male
Prosthesis Design
Rabbits
Stents*