Activation of human bitter taste receptors by polymethoxylated flavonoids

Yuki Kuroda; Riko Ikeda; Toyomi Yamazaki; Keisuke Ito; Kazunari Uda; Keiji Wakabayashi; Tatsuo Watanabe

doi:10.1080/09168451.2016.1184558

Activation of human bitter taste receptors by polymethoxylated flavonoids

Biosci Biotechnol Biochem. 2016 Oct;80(10):2014-7. doi: 10.1080/09168451.2016.1184558. Epub 2016 Jul 4.

Authors

Yuki Kuroda¹, Riko Ikeda¹, Toyomi Yamazaki¹, Keisuke Ito¹, Kazunari Uda¹, Keiji Wakabayashi¹, Tatsuo Watanabe¹

Affiliation

¹ a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.

PMID: 27379685
DOI: 10.1080/09168451.2016.1184558

Abstract

Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.

Keywords: hTAS2R14; hTAS2R46; nobiletin; polymethoxylated flavonoids; tangeretin.

MeSH terms

Flavones / chemistry*
Flavones / pharmacology*
HEK293 Cells
Humans
Receptors, G-Protein-Coupled / metabolism*

Substances

Flavones
Receptors, G-Protein-Coupled
nobiletin
tangeretin