The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease

Biomed Res Int. 2016:2016:5683097. doi: 10.1155/2016/5683097. Epub 2016 Jun 9.

Abstract

Parkinson's disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / pathology
  • Brain / physiopathology*
  • Disease Models, Animal*
  • Humans
  • Parkinson Disease / pathology
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / therapy*
  • Stem Cell Research*
  • Stem Cell Transplantation / methods*
  • Treatment Outcome