Pulmonary Sarcoidosis: Diagnosis and Treatment

Mayo Clin Proc. 2016 Jul;91(7):946-54. doi: 10.1016/j.mayocp.2016.03.004.

Abstract

Sarcoidosis is a chronic granulomatous disease of unknown cause that is seen worldwide and occurs mainly in patients between the ages of 20 and 60 years. It can be difficult to diagnose because it can mimic many other diseases including lymphoproliferative disorders and granulomatous infections and because there is no specific test for diagnosis, which depends on correlation of clinicoradiologic and histopathologic features. This review will focus on recent discoveries regarding the pathogenesis of sarcoidosis, common clinical presentations, diagnostic evaluation, and indications for treatment. This review is aimed largely at general practitioners and emphasizes the importance of differentiating pulmonary sarcoidosis from its common imitators.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Age Distribution
  • Diagnosis, Differential
  • Humans
  • Incidence
  • Incidental Findings
  • Lymphadenopathy / diagnostic imaging
  • Lymphadenopathy / etiology*
  • Middle Aged
  • Radiography, Thoracic
  • Sarcoidosis, Pulmonary* / diagnostic imaging
  • Sarcoidosis, Pulmonary* / epidemiology
  • Sarcoidosis, Pulmonary* / physiopathology
  • Sarcoidosis, Pulmonary* / therapy
  • Young Adult

Substances

  • Adrenal Cortex Hormones