Objectives: This meta-analysis summarized the risks that reintubation impose on ventilator-associated pneumonia (VAP) and mortality.
Background: Extubation failure increases the probability of poor clinical outcomes pertaining to mechanical ventilation.
Methods: Literature published during a 15-year period was retrieved from PubMed, Web of Knowledge databases, the Embase (Excerpa Medica database), and the Cochrane Library. Data involving reintubation, VAP, and mortality were extracted for a meta-analysis.
Results: Forty-one studies involving 29,923 patients were enrolled for the analysis. The summary odds ratio (OR) between VAP and reintubation was 7.57 (95% confidence interval [CI] = 3.63-15.81). The merged ORs for mortality in hospital and intensive care unit were 3.33 (95% CI = 2.02-5.49) and 7.50 (95% CI = 4.60-12.21), respectively.
Conclusions: Reintubation can represent a threat to survival and increase the risk of VAP. The risk of mortality after reintubation differs between planned and unplanned extubation. Extubation failure is associated with a higher risk of VAP in the cardiac surgery population than in the general population.
Keywords: Extubation failure; Mortality; Reintubation; Ventilator-associated pneumonia.
Copyright © 2016 Elsevier Inc. All rights reserved.