Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells

Jisun Oh; Lynn Hlatky; Yong-Seob Jeong; Dohoon Kim

doi:10.3390/toxins8070199

Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells

Toxins (Basel). 2016 Jun 30;8(7):199. doi: 10.3390/toxins8070199.

Authors

Jisun Oh¹, Lynn Hlatky², Yong-Seob Jeong³, Dohoon Kim⁴

Affiliations

¹ School of Food Science and Biotechnology (BK21 Plus), Kyungpook National University, Daegu 41566, Korea. j.oh@knu.ac.kr.
² Center of Cancer Systems Biology, Tufts University School of Medicine, Boston, MA 02135, USA. hlatky@cancer-systems-biology.org.
³ Department of Food Science and Technology, Chonbuk National University, Jeonju 54896, Korea. ysjeong@jbnu.ac.kr.
⁴ Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111, USA. dohoon.kim@tufts.edu.

Abstract

Understanding how to target cancer stem cells (CSCs) may provide helpful insights for the development of therapeutic or preventive strategies against cancers. Dietary phytochemicals with anticancer properties are promising candidates and have selective impact on CSCs. This review summarizes the influence of phytochemicals on heterogeneous cancer cell populations as well as on specific targeting of CSCs.

Keywords: anticancer; cancer; cancer stem cells; phytochemicals; polyphenols.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / therapeutic use*
Biomarkers, Tumor / metabolism
Humans
Molecular Targeted Therapy
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Neoplastic Stem Cells / drug effects*
Neoplastic Stem Cells / metabolism
Neoplastic Stem Cells / pathology
Phenotype
Phytochemicals / therapeutic use*
Signal Transduction / drug effects

Substances

Antineoplastic Agents, Phytogenic
Biomarkers, Tumor
Phytochemicals