Conversion of Vindoline into 11-Mesyloxytabersonine

Chem Pharm Bull (Tokyo). 2016;64(7):800-4. doi: 10.1248/cpb.c16-00175.

Abstract

Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.

MeSH terms

  • Indole Alkaloids / chemical synthesis*
  • Indole Alkaloids / chemistry
  • Molecular Conformation
  • Vinblastine / analogs & derivatives*
  • Vinblastine / chemistry

Substances

  • 11-mesyloxytabersonine
  • Indole Alkaloids
  • vindoline
  • Vinblastine