Autophagy modulators regulate survival motor neuron protein stability in motoneurons

Exp Neurol. 2016 Sep;283(Pt A):287-97. doi: 10.1016/j.expneurol.2016.06.032. Epub 2016 Jun 30.
No abstract available

Keywords: Autophagosome; Autophagy; Calpain; Motoneuron; Rapamycin; Spinal Muscular Atrophy; Survival motor neuron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Autophagy / drug effects
  • Autophagy / genetics
  • Autophagy / physiology*
  • Cell Survival / genetics
  • Cell Survival / physiology
  • Cells, Cultured
  • Disease Models, Animal
  • Embryo, Mammalian
  • Enzyme Inhibitors / pharmacology
  • Gene Expression Regulation, Developmental / drug effects
  • Gene Expression Regulation, Developmental / genetics
  • Gene Expression Regulation, Developmental / physiology
  • Macrolides / pharmacology
  • Mice
  • Mice, Transgenic
  • Motor Neurons / drug effects
  • Motor Neurons / metabolism*
  • Motor Neurons / ultrastructure
  • Muscular Atrophy, Spinal / genetics
  • Muscular Atrophy, Spinal / pathology*
  • Nerve Growth Factors / pharmacology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Sequestosome-1 Protein / metabolism
  • Spinal Cord / cytology
  • Spinal Cord / growth & development
  • Survival of Motor Neuron 1 Protein / genetics
  • Survival of Motor Neuron 1 Protein / metabolism
  • Survival of Motor Neuron 2 Protein / genetics
  • Survival of Motor Neuron 2 Protein / metabolism

Substances

  • Enzyme Inhibitors
  • Macrolides
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • SMN2 protein, human
  • SQSTM1 protein, human
  • Sequestosome-1 Protein
  • Smn1 protein, mouse
  • Survival of Motor Neuron 1 Protein
  • Survival of Motor Neuron 2 Protein
  • bafilomycin A1