An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation

Cancer Discov. 2016 Jul;6(7):700-2. doi: 10.1158/2159-8290.CD-16-0564.

Abstract

Histone H3 lysine 36 dimethylation (H3K36me2), a modification associated with transcriptional activation, is required for mixed-lineage leukemia-dependent transcription and leukemic transformation. In this issue of Cancer Discovery, Zhu and colleagues map the network of readers, writers, and erasers of H3K36me2 and uncover the ASH1L histone methyltransferase as a novel target for therapeutic intervention. Cancer Discov; 6(7); 700-2. ©2016 AACR.See related article by Zhu and colleagues, p. 770.

Publication types

  • Letter
  • Comment

MeSH terms

  • DNA-Binding Proteins / metabolism
  • Epigenesis, Genetic
  • Gene Expression Regulation, Leukemic
  • Hematopoiesis / genetics
  • Histone-Lysine N-Methyltransferase
  • Histones / metabolism*
  • Humans
  • Leukemia / drug therapy
  • Leukemia / genetics*
  • Leukemia / metabolism*
  • Lysine / metabolism
  • Methylation
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Transcription Factors / metabolism
  • Translocation, Genetic*

Substances

  • DNA-Binding Proteins
  • Histones
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • ASH1L protein, human
  • Histone-Lysine N-Methyltransferase
  • Lysine