Mitochondrial Networking in T Cell Memory

Marc Liesa; Orian S Shirihai

doi:10.1016/j.cell.2016.06.035

Mitochondrial Networking in T Cell Memory

Cell. 2016 Jun 30;166(1):9-10. doi: 10.1016/j.cell.2016.06.035.

Authors

Marc Liesa¹, Orian S Shirihai²

Affiliations

¹ Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: mliesa@mednet.ucla.edu.
² Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: oshirihai@mednet.ucla.edu.

PMID: 27368094
DOI: 10.1016/j.cell.2016.06.035

Abstract

T-lymphocytes show large changes in ATP demand and nutrient utilization, imposed by their different roles as T memory and T effector cells. Therefore, T cell remodeling represents a bioenergetic challenge to mitochondria. New work from Buck et al. links changes in mitochondrial shape to T cell fate choice.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Energy Metabolism
Humans
Immunologic Memory
Mitochondria / metabolism*
T-Lymphocytes*