Caries management by risk assessment (CAMBRA) is an evidence-based model intended to provide dentists with a protocol for diagnosis, treatment, and prevention of caries by assessing and addressing a patient's overall oral health. The aim of this review was to examine the literature on CAMBRA to determine its efficacy. Clinical studies demonstrate that the CAMBRA approach is an effective concept that is both predictive of dental caries development and accurate in outlining appropriate treatment options and preventive strategies that can reduce the morbidity of this common disease process across all patient demographics.