Colonization and effector functions of innate lymphoid cells in mucosal tissues

Myunghoo Kim; Chang H Kim

doi:10.1016/j.micinf.2016.06.005

Colonization and effector functions of innate lymphoid cells in mucosal tissues

Microbes Infect. 2016 Oct;18(10):604-614. doi: 10.1016/j.micinf.2016.06.005. Epub 2016 Jun 27.

Authors

Myunghoo Kim¹, Chang H Kim²

Affiliations

¹ Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Weldon School of Biomedical Engineering, Purdue Institute of Inflammation, Immunology and Infectious Diseases, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
² Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Weldon School of Biomedical Engineering, Purdue Institute of Inflammation, Immunology and Infectious Diseases, Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: chkim@purdue.edu.

Abstract

Innate lymphoid cells (ILCs) protect mucosal barrier tissues to fight infection and maintain tissue integrity. ILCs and their progenitors are developmentally programmed to migrate, differentiate and populate various mucosal tissues and associated lymphoid tissues. Functionally mature ILC subsets respond to diverse pathogens such as bacteria, viruses, fungi and parasites in subset-specific manners. In this review, we will discuss how ILCs populate mucosal tissues and regulate immune responses to distinct pathogens to protect the host and maintain tissue integrity.

Keywords: Infection; Innate lymphoid cells; Intestine; Migration; Mucosal tissues.

Publication types

Review

MeSH terms

Animals
Bacteria / immunology
Fungi / immunology
Humans
Immunity, Innate*
Immunity, Mucosal*
Lymphocytes / immunology*
Mucous Membrane / immunology*
Parasites / immunology
Viruses / immunology

Abstract

Publication types

MeSH terms

Grants and funding