[Central nervous system lymphoma revealed by lymphocytic meningitis in a patient with systemic lupus erythematosus: An unusual association]

M Roriz; A Lopes; I Jarrin; S Lechtman; M Polivka; J-F Bergmann; D Sène; S Mouly

doi:10.1016/j.revmed.2016.05.019

[Central nervous system lymphoma revealed by lymphocytic meningitis in a patient with systemic lupus erythematosus: An unusual association]

Rev Med Interne. 2017 Apr;38(4):269-273. doi: 10.1016/j.revmed.2016.05.019. Epub 2016 Jun 27.

[Article in French]

Authors

M Roriz¹, A Lopes², I Jarrin², S Lechtman³, M Polivka⁴, J-F Bergmann³, D Sène³, S Mouly³

Affiliations

¹ Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France. Electronic address: melanie.roriz@aphp.fr.
² Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
³ Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France.
⁴ Service d'anatomopathologie, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.

PMID: 27363932
DOI: 10.1016/j.revmed.2016.05.019

Abstract

Introduction: We report an unusual observation of central nervous system (CNS) lymphoma in a 60-year-old woman with systemic lupus erythematosus and fatal outcome.

Observation: The patient had systemic erythematosus lupus for 7 years, treated with mycophenolate mofetil and developed lymphocytic meningitis in 2015 associated to the presence of EBV in the cerebrospinal fluid and a necrotic vermis' lesion. Diagnosis of large B-cell lymphoma was histologically confirmed from stereotaxic biopsy, shortly before she died from neurological complications.

Conclusion: Even though the current association is unusual, lymphocytic meningitis with hypoglycorrachia in patients with systemic lupus erythematosus may reveal CNS lymphoma and diagnosis confirmation requires stereotaxic biopsy in order not to delay specific therapeutic management.

Keywords: Central nervous system; Lupus érythémateux systémique; Lymphoma; Lymphome; Meningitis; Méningite; Systemic erythematosus lupus; Système nerveux central.

Publication types

Case Reports

MeSH terms

Central Nervous System Neoplasms / complications
Central Nervous System Neoplasms / diagnosis*
Diagnosis, Differential
Fatal Outcome
Female
Humans
Leukemic Infiltration / complications
Lupus Erythematosus, Systemic / complications
Lupus Erythematosus, Systemic / diagnosis*
Lymphoma / complications
Lymphoma / diagnosis*
Meningitis / diagnosis*
Meningitis / etiology
Middle Aged