[Histological grading of breast cancer]

M Christgen; F Länger; H Kreipe

doi:10.1007/s00292-016-0182-8

[Histological grading of breast cancer]

Pathologe. 2016 Jul;37(4):328-36. doi: 10.1007/s00292-016-0182-8.

[Article in German]

Authors

M Christgen¹, F Länger², H Kreipe²

Affiliations

¹ Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Deutschland. Christgen.Matthias@MH-Hannover.de.
² Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Deutschland.

PMID: 27363708
DOI: 10.1007/s00292-016-0182-8

Abstract

From a historical perspective, histological grading was the earliest cell-based method for assessing tumor biology and the prognosis of breast cancer. This review article provides detailed and practical instructions for grading of breast cancer in routine diagnostics. Furthermore, the increasing relevance of precise histological grading in the era of molecular pathology is discussed.

Keywords: Mitotic activity; Nuclear pleomorphism; Prognosis; Tubule formation; Tumor biology.

Publication types

Review

MeSH terms

Biomarkers, Tumor / analysis
Breast / pathology
Breast Neoplasms / classification
Breast Neoplasms / pathology*
Breast Neoplasms / therapy
Carcinoma, Ductal, Breast / classification
Carcinoma, Ductal, Breast / pathology*
Carcinoma, Ductal, Breast / therapy
Cell Nucleus / pathology
Cell Transformation, Neoplastic / pathology
Combined Modality Therapy
Female
Humans
Ki-67 Antigen / analysis
Microtubules / pathology
Mitotic Index
Neoplasm Grading / methods
Neoplasm Invasiveness / pathology
Prognosis

Substances

Biomarkers, Tumor
Ki-67 Antigen