Hypoxic ischemic encephalopathy (HIE), one of the common causes of newborn invalidism, is likely to induce nervous system-associated sequelae and even intracranial hemorrhage in severe cases. The incidence rate of HIE has been rising in recent years. In order to study the clinical nursing effect for HIE combined with intracranial hemorrhage, 76 newborns diagnosed with HIE combined with intracranial hemorrhage by spiral computed tomography (CT) from the of Binzhou Peoples Hospital, Shandong, China were selected. They were divided into a control group and an intervention group. The control group received routine nursing, while the intervention group received comprehensive nursing intervention. The experimental results suggested that the mental developmental index (MDI) value and the psychomotor developmental index (PDI) value of patients in the intervention group were much higher than those of the control group and the difference was significant (p<0.05). The curative effect of the intervention group was remarkably better than that of the control group and the difference was also statistically significant (p less than 0.05). Moreover, the intervention group had a lower incidence rate of untoward reactions. All the findings suggest that comprehensive nursing intervention can help newborns diagnosed with HIE combined with intracranial hemorrhage recover more effectively, therefore is worth applying.