A dinuclear ruthenium(II) complex as turn-on luminescent probe for hypochlorous acid and its application for in vivo imaging

Zonglun Liu; Kuo Gao; Beng Wang; Hui Yan; Panfei Xing; Chongmin Zhong; Yongqian Xu; Hongjuan Li; Jianxin Chen; Wei Wang; Shiguo Sun

doi:10.1038/srep29065

A dinuclear ruthenium(II) complex as turn-on luminescent probe for hypochlorous acid and its application for in vivo imaging

Sci Rep. 2016 Jun 30:6:29065. doi: 10.1038/srep29065.

Authors

Zonglun Liu¹, Kuo Gao², Beng Wang¹, Hui Yan¹, Panfei Xing¹, Chongmin Zhong¹, Yongqian Xu¹, Hongjuan Li¹, Jianxin Chen², Wei Wang², Shiguo Sun¹

Affiliations

¹ College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China.
² Beijing University of Chinese Medicine, No. 11 Beisanhuandonglu, Chaoyang District, Beijing, 100029, China.

Abstract

A dinuclear ruthenium(II) complex Ruazo was designed and synthesized, in which oxidative cyclization of the azo and o-amino group was employed for the detection of hypochlorous acid (HClO) in aqueous solution. The non-emissive Ruazo formed highly luminescent triazole-ruthenium(II) complex in presence of HClO and successfully imaged HClO in living cell and living mouse.

Publication types

Research Support, Non-U.S. Gov't