Tumor microenvironment on the move and the Aselli connection

Jeffrey J Rodvold; Maurizio Zanetti

doi:10.1126/scisignal.aag2279

Tumor microenvironment on the move and the Aselli connection

Sci Signal. 2016 Jun 28;9(434):fs13. doi: 10.1126/scisignal.aag2279.

Authors

Jeffrey J Rodvold¹, Maurizio Zanetti²

Affiliations

¹ The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0815, USA.
² The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0815, USA. mzanetti@ucsd.edu.

PMID: 27353363
DOI: 10.1126/scisignal.aag2279

Abstract

The tumor microenvironment is involved in many activities that promote tumor cell growth, local spreading, and metastasis. In this issue of Science Signaling, Jung et al found that lymphangiogenesis may result from the cooperation of two molecules, sphingosine-1-phosphate (S1P) and lipocalin 2 (LCN2), produced by tumor cells and macrophages, respectively. The new S1P-LCN2 axis stresses the importance of innate immunity in remodeling the tumor microenvironment and in lymphangiogenesis.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Animals
Humans
Lipocalin-2 / metabolism*
Lysophospholipids / metabolism*
Neoplasm Proteins / metabolism*
Neoplasms / metabolism*
Signal Transduction*
Sphingosine / analogs & derivatives*
Sphingosine / metabolism
Tumor Microenvironment*

Substances

LCN2 protein, human
Lipocalin-2
Lysophospholipids
Neoplasm Proteins
sphingosine 1-phosphate
Sphingosine