Clinical application of extracorporeal membrane oxygenation in children with refractory cardiopulmonary failure

World J Pediatr. 2016 Aug;12(3):364-367. doi: 10.1007/s12519-016-0030-1. Epub 2016 Jun 29.

Abstract

Background: This study aimed to discribe the experience in supporting children with refractory cardiopulmonary failure with extracorporeal membrane oxygenation (ECMO).

Methods: We retrospectively reviewed 12 children with refractory cardiopulmonary failure supported with ECMO from February 2009 to August 2015 in the Pediatric Intensive Care Unit (PICU), Children's Hospital, Zhejiang University School of Medicine.

Results: Seven of the 12 patients were weaned successfully from ECMO and dischaged from the hospital, with a survival rate of 58.3% (7/12). Among them, five patients had acute fulminant myocarditis (AFM). Complications during ECMO included hemorrhage, hemolysis, thrombosis, acute kidney injury, and secondary hematogenous infection. During 1-24 month follow-up, the seven surviving patients recovered with normal cardiopulmonary function.

Conclusions: ECMO is useful for supporting children with refractory cardiopulmonary failure, especially for treatment of AFM.

Keywords: acute fulminant myocarditis; acute respiratory distress syndrome; extracorporeal membrane oxygenation.

MeSH terms

  • Child
  • Child, Preschool
  • China
  • Cohort Studies
  • Critical Illness / mortality
  • Critical Illness / therapy
  • Extracorporeal Membrane Oxygenation / methods*
  • Extracorporeal Membrane Oxygenation / mortality
  • Female
  • Heart Failure / diagnosis
  • Heart Failure / mortality
  • Heart Failure / therapy*
  • Hospital Mortality
  • Humans
  • Infant
  • Infant, Newborn
  • Intensive Care Units, Pediatric
  • Male
  • Myocarditis / diagnosis
  • Myocarditis / mortality
  • Myocarditis / therapy*
  • Prognosis
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / mortality
  • Respiratory Distress Syndrome / therapy*
  • Retrospective Studies
  • Risk Assessment
  • Survival Analysis
  • Treatment Outcome