Effects of NSAIDs on the risk factors of colorectal cancer: a mini review

Takahiro Hamoya; Gen Fujii; Shingo Miyamoto; Mami Takahashi; Yukari Totsuka; Keiji Wakabayashi; Jiro Toshima; Michihiro Mutoh

doi:10.1186/s41021-016-0033-0

Effects of NSAIDs on the risk factors of colorectal cancer: a mini review

Genes Environ. 2016 Apr 1:38:6. doi: 10.1186/s41021-016-0033-0. eCollection 2016.

Authors

Takahiro Hamoya¹, Gen Fujii², Shingo Miyamoto³, Mami Takahashi⁴, Yukari Totsuka², Keiji Wakabayashi⁵, Jiro Toshima⁶, Michihiro Mutoh⁷

Affiliations

¹ Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan ; Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, , Katsusika-ku Tokyo, 125-8585 Japan.
² Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan.
³ Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan.
⁴ Central Animal Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan.
⁵ Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku Shizuoka, 422-8526 Japan.
⁶ Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, , Katsusika-ku Tokyo, 125-8585 Japan.
⁷ Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan ; Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan.

Abstract

Evidence from epidemiological and experimental studies has shown that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colorectal cancer (CRC). The function of NSAIDs and the molecular targets for chemopreventive effects on CRC have been extensively studied and their data were reported. However, the relation between NSAIDs and the risk factors of CRC have not been fully elucidated yet. Thus, relations between NSAIDs and the risk factors of CRC, such as overweight and obesity, alcohol, aging, hypertriglyceridemia and smoking, are summarized with our data and with recent reported data in this review.

Keywords: Chemoprevention; Colorectal cancer; Non-steroidal anti-inflammatory drugs; Risk factors.

Publication types

Review