Joint effects of objectively-measured sedentary time and physical activity on all-cause mortality

Abstract

Objective: Examine the joint effects of objectively-measured sedentary time and moderate-to-vigorous physical activity (MVPA) on all-cause mortality.

Methods: The present study included data from the 2003-2006 National Health & Nutrition Examination Survey, with mortality follow-up data (via National Death Index) through 2011 (N=5575U.S. adults). Sedentary time (activity counts/min between 0 and 99) and MVPA (activity counts/min ≥2020) were objectively measured using the ActiGraph 7164 accelerometer.

Results: The median age of the participants was 50yrs; proportion of men was 50.2%; proportion of whites was 53.8%, 18.7% for blacks; median follow-up was 81months; and 511 deaths occurred over the follow-up period. After adjusting for age, gender, race-ethnicity, cotinine, weight status, poverty level, C-reactive protein and comorbid illness (summed score of 0-8 chronic diseases), and for a 1min increase in MVPA and sedentary time, both MVPA (HRadjusted=0.98; 95% CI: 0.96-0.99; P=0.04) and sedentary time (HRadjusted=1.001; 95% CI: 1.0003-1.002; P=0.008) were independently associated with all-cause mortality. Further, MVPA was associated with all-cause mortality among those with greater (above median) sedentary time (HRadjusted=0.95; 95% CI: 0.93-0.97; P<.001). Sedentary time was not associated with all-cause mortality among those engaging in above median levels of MVPA (HRadjusted=0.998; 95% CI: 0.996-1.001; P=.32), but sedentary time was associated with increased mortality risk among those below median levels of MVPA (HR=1.002; 95% CI: 1.001-1.003; P<0.001).

Conclusions: Sedentary time and MVPA are independently associated with all-cause mortality. Above median sedentary time levels did not negate the beneficial effects of MVPA on all-cause mortality risk.

Keywords: Epidemiology; NHANES; Survival.