Abstract
A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain-Barré syndrome associated with infection. In this review, we discuss the recent literature on ZIKV-host interactions, including new mechanistic insight concerning the basis of ZIKV-induced neuropathogenesis.
MeSH terms
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Aedes / virology
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Animals
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Disease Outbreaks*
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Female
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Fetus
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Guillain-Barre Syndrome / epidemiology
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Guillain-Barre Syndrome / etiology
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Guillain-Barre Syndrome / pathology*
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Guillain-Barre Syndrome / virology
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Host-Pathogen Interactions
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Humans
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Latin America / epidemiology
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Microcephaly / epidemiology
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Microcephaly / etiology
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Microcephaly / pathology*
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Microcephaly / virology
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Mosquito Vectors / virology
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Placenta / pathology
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Placenta / virology
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Pregnancy
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Virion / pathogenicity*
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Virion / physiology
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Zika Virus / pathogenicity*
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Zika Virus / physiology
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Zika Virus Infection / complications*
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Zika Virus Infection / epidemiology
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Zika Virus Infection / transmission
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Zika Virus Infection / virology