Pancreatic surgical operations, being very traumatic, cause considerable and lasting disorders on the part of external respiration, gas exchange, and central and regional hemodynamics. Patients with pancreatic tumors show systolic myocardial strain, which may be related to increased sympatho-adrenal influences. In the early days after pancreatoduodenal resection for pancreatic tumors, patients develop hyperdynamic circulation. Extensive use of neuropeptides is indicated as part of combined treatment preventing postoperative complications after pancreatic surgery.