Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy

Huijun Phoebe Tham; Hongzhong Chen; Yu Hui Tan; Qiuyu Qu; Sivaramapanicker Sreejith; Lingzhi Zhao; Subbu S Venkatraman; Yanli Zhao

doi:10.1039/c6cc03076a

Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy

Chem Commun (Camb). 2016 Jul 7;52(57):8854-7. doi: 10.1039/c6cc03076a.

Authors

Huijun Phoebe Tham¹, Hongzhong Chen², Yu Hui Tan², Qiuyu Qu², Sivaramapanicker Sreejith², Lingzhi Zhao², Subbu S Venkatraman³, Yanli Zhao⁴

Affiliations

¹ Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore and Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg and School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. assubbu@ntu.edu.sg.
² Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg.
³ School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. assubbu@ntu.edu.sg.
⁴ Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg and School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. assubbu@ntu.edu.sg.

PMID: 27346609
DOI: 10.1039/c6cc03076a

Abstract

Silylated zinc phthalocyanine (ZnPc) was anchored onto silica-coated gold nanorods (AuNR) with retained local surface plasmon resonance (LSPR). Independent LSPR and singlet oxygen production of anchored ZnPc enhance the photothermal and photodynamic efficacy of the obtained AuNR-Si-ZnPc under NIR light excitation. AuNR-Si-ZnPc was further grafted with hyaluronic acid (HA). Since HA has selective targeting capability to CD44 antigens, the final hybrid could target cancer cells directly for synergistic photothermal and photodynamic therapy.