Flexible Substrate-Based Devices for Point-of-Care Diagnostics

ShuQi Wang; Thiruppathiraja Chinnasamy; Mark A Lifson; Fatih Inci; Utkan Demirci

doi:10.1016/j.tibtech.2016.05.009

Flexible Substrate-Based Devices for Point-of-Care Diagnostics

Trends Biotechnol. 2016 Nov;34(11):909-921. doi: 10.1016/j.tibtech.2016.05.009. Epub 2016 Jun 22.

Authors

ShuQi Wang¹, Thiruppathiraja Chinnasamy², Mark A Lifson², Fatih Inci², Utkan Demirci³

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang Province, 310003, China; Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310029, China; Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA. Electronic address: shuqi@zju.edu.cn.
² Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA.
³ Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA; Department of Electrical Engineering (by courtesy), Stanford University, Stanford, CA 94305, USA. Electronic address: utkan@stanford.edu.

Abstract

Point-of-care (POC) diagnostics play an important role in delivering healthcare, particularly for clinical management and disease surveillance in both developed and developing countries. Currently, the majority of POC diagnostics utilize paper substrates owing to affordability, disposability, and mass production capability. Recently, flexible polymer substrates have been investigated due to their enhanced physicochemical properties, potential to be integrated into wearable devices with wireless communications for personalized health monitoring, and ability to be customized for POC diagnostics. Here, we focus on the latest advances in developing flexible substrate-based diagnostic devices, including paper and polymers, and their clinical applications.

Keywords: flexible substrate; paper; point-of-care diagnostics; polymer; wearable devices.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Clothing
Humans
Lab-On-A-Chip Devices
Microfluidic Analytical Techniques / instrumentation*
Monitoring, Physiologic / instrumentation*
Paper
Pliability
Point-of-Care Systems*
Polymers
Textiles

Substances

Polymers

Abstract

Publication types

MeSH terms

Substances

Grants and funding