Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound

Mini Rev Med Chem. 2017;17(1):62-77. doi: 10.2174/1389557516666160624124127.

Abstract

Gentiopicroside is a secoiridoid compound isolated from Gentiana lutea which is called Qin Jiao in Chinese. It is one of the most common herbal medicines used in China. In this article, we review the pharmacological and biological activity (antiviral, anti-inflammatory, analgesia, antihepatotoxic and choleretic), as well as biotransformation of the gentiopicroside. In addition, attempt towards the total synthesis of gentiopicroside is also presented.

Publication types

  • Review

MeSH terms

  • Analgesics / chemistry
  • Analgesics / isolation & purification
  • Analgesics / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology
  • Biological Products / chemistry
  • Biological Products / isolation & purification
  • Biological Products / pharmacology*
  • Biotransformation
  • Cholagogues and Choleretics / chemistry
  • Cholagogues and Choleretics / isolation & purification
  • Cholagogues and Choleretics / pharmacology
  • Gentiana / chemistry
  • Humans
  • Iridoid Glucosides / chemistry
  • Iridoid Glucosides / isolation & purification
  • Iridoid Glucosides / pharmacology*
  • Molecular Structure
  • Protective Agents / chemistry
  • Protective Agents / isolation & purification
  • Protective Agents / pharmacology

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiviral Agents
  • Biological Products
  • Cholagogues and Choleretics
  • Iridoid Glucosides
  • Protective Agents
  • gentiopicroside