Recently, several new randomized controlled trials have been reported which showed the efficacy of neuroendovascular therapy for acute ischemic stroke. Confirming the major vessel occlusion in the proximal anterior circulation, limited ischemic core and preserved ischemic penumbra, using stent retrievers to achieve successful reperfusion, and shortening the onset-to-reperfusion time were the essential factors to achieve good clinical outcome. With these new evidences, it has been proved that neuroendovascular therapy became one of the standard treatments for acute ischemic stroke.