Comparative proteomic data of M13SV1 human breast epithelial cells and their tumorigenic variants under treatment with estrogenic compounds

Albert Braeuning; Claudia Schmidt; Axel Oberemm; Alfonso Lampen

doi:10.1016/j.dib.2016.05.052

Comparative proteomic data of M13SV1 human breast epithelial cells and their tumorigenic variants under treatment with estrogenic compounds

Data Brief. 2016 May 30:8:329-33. doi: 10.1016/j.dib.2016.05.052. eCollection 2016 Sep.

Authors

Albert Braeuning¹, Claudia Schmidt¹, Axel Oberemm¹, Alfonso Lampen¹

Affiliation

¹ German Federal Institute for Risk Assessment, Department Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.

Abstract

Data from a comparative proteomic analysis of three human breast epithelial cell lines are presented. M13SV1 cells and their tumorigenic derivatives M13SV1-R2-2 and M13SV1-R2-N1 were used. Proteomic data were obtained using 2-dimensional gel electrophoresis and subsequent identification of proteins by MALDI-TOF mass spectrometry. In a second experiment, the three cell lines were treated with different concentrations of the estrogenic compounds β-estradiol or genistein and alterations in protein expression were monitored by 2-dimensional gel electrophoresis and MALDI-TOF mass spectrometry. Presented data provide a comprehensive overview of proteomic differences between the three cell lines and their response to estrogenic stimulation.