Oxidative stress markers in Thoroughbred horses after castration surgery under inhalation anesthesia

Nao Tsuzuki; Naoki Sasaki; Kanichi Kusano; Yoshiro Endo; Shidow Torisu

doi:10.1294/jes.27.77

Oxidative stress markers in Thoroughbred horses after castration surgery under inhalation anesthesia

J Equine Sci. 2016;27(2):77-9. doi: 10.1294/jes.27.77. Epub 2016 Jun 21.

Authors

Nao Tsuzuki¹, Naoki Sasaki², Kanichi Kusano³, Yoshiro Endo⁴, Shidow Torisu⁵

Affiliations

¹ Laboratory of Veterinary Surgery, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
² Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido 080-8555, Japan.
³ Japan Racing Association Miho Training Center, Ibaraki 300-0493, Japan.
⁴ Japan Racing Association Miyazaki Yearling Training Farm, Miyazaki 880-0036, Japan.
⁵ Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.

Abstract

Oxidative stress has been reported to occur during surgery. It is important to reduce intraoperative oxidative stress to improve the postoperative prognosis. However, there are no reports regarding oxidative stress related to surgery in horses. In the present study, we measured pre and postsurgical diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP); the oxidative stress index (OSI) was then calculated (OSI=d-ROMs/BAP × 100). d-ROMs were not significantly different between the pre and postsurgical periods. However, BAP significantly decreased after surgery (P=0.02), and OSI significantly increased after surgery (P=0.02). Based on these results, it suggested that castration surgery under inhalation anesthesia decreases the antioxidant potential and causes oxidative stress in horses.

Keywords: Thoroughbred; oxidative stress; surgery.