Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae)

Dewa Gede Katja; Kindi Farabi; Nurlelasari; Desi Harneti; Tri Mayanti; Unang Supratman; Khalijah Awang; Hideo Hayashi

doi:10.1080/10286020.2016.1196671

Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae)

J Asian Nat Prod Res. 2017 Feb;19(2):194-200. doi: 10.1080/10286020.2016.1196671. Epub 2016 Jun 22.

Authors

Dewa Gede Katja^{1

2}, Kindi Farabi¹, Nurlelasari¹, Desi Harneti¹, Tri Mayanti¹, Unang Supratman¹, Khalijah Awang³, Hideo Hayashi⁴

Affiliations

¹ a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
² b Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Sam Ratulangi , Manado 95115 , Indonesia.
³ c Faculty of Science, Department of Chemistry , University of Malaya , Kuala Lumpur 59100 , Malaysia.
⁴ d Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences , Osaka Prefecture University , Osaka 599-8531 , Japan.

PMID: 27329305
DOI: 10.1080/10286020.2016.1196671

Abstract

A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost-9(11),24(24')-diene (1), along with 3β-hydroxy-lanost-7-ene (2) and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC₅₀ values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.

Keywords: Chisocheton cumingianus; Lanostane-type triterpenoid; Meliaceae; cytotoxic activity.

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Lanosterol / analogs & derivatives
Leukemia P388
Meliaceae / chemistry*
Mice
Molecular Structure
Plant Bark / chemistry*
Sitosterols / chemistry
Sitosterols / isolation & purification*
Sitosterols / pharmacology
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*

Substances

3beta-hydroxy-25-ethyl-lanost-9(11),24(24')-diene
3beta-hydroxy-lanost-7-ene
Antineoplastic Agents, Phytogenic
Sitosterols
Triterpenes
beta-sitosterol-3-O-acetate
Lanosterol