Comparison of serum Neuregulin 4 (Nrg4) levels in adults with newly diagnosed type 2 diabetes mellitus and controls without diabetes

Yea Eun Kang; Ji Min Kim; Sorim Choung; Kyong Hye Joung; Ju Hee Lee; Hyun Jin Kim; Bon Jeong Ku

doi:10.1016/j.diabres.2016.04.007

Comparison of serum Neuregulin 4 (Nrg4) levels in adults with newly diagnosed type 2 diabetes mellitus and controls without diabetes

Diabetes Res Clin Pract. 2016 Jul:117:1-3. doi: 10.1016/j.diabres.2016.04.007. Epub 2016 Apr 23.

Authors

Yea Eun Kang¹, Ji Min Kim¹, Sorim Choung¹, Kyong Hye Joung¹, Ju Hee Lee¹, Hyun Jin Kim², Bon Jeong Ku³

Affiliations

¹ Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
² Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: kimhj43@cnuh.co.kr.
³ Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: bonjeong@cnu.ac.kr.

PMID: 27329015
DOI: 10.1016/j.diabres.2016.04.007

Abstract

We explored the role of Neuregulin 4 (Nrg4), a newly described factor secreted by adipose tissue, by measuring serum Nrg4 levels in humans. Circulating Nrg4 levels were significantly higher in patients with diabetes mellitus compared with controls without diabetes and were correlated with the serum glucose level and insulin resistance.

Keywords: Adipokine; Diabetes mellitus; Neuregulin 4.

Publication types

Comparative Study

MeSH terms

Adult
Biomarkers / blood*
Blood Glucose / analysis*
Case-Control Studies
Diabetes Mellitus, Type 2 / blood*
Diabetes Mellitus, Type 2 / diagnosis*
Female
Humans
Insulin Resistance*
Male
Middle Aged
Neuregulins / blood*

Substances

Biomarkers
Blood Glucose
Neuregulins
neuregulin-4