Local injection of bone marrow progenitor cells for the treatment of anal sphincter injury: in-vitro expanded versus minimally-manipulated cells

Stem Cell Res Ther. 2016 Jun 21;7(1):85. doi: 10.1186/s13287-016-0344-x.

Abstract

Background: Anal incontinence is a disabling condition that adversely affects the quality of life of a large number of patients, mainly with anal sphincter lesions. In a previous experimental work, in-vitro expanded bone marrow (BM)-derived mesenchymal stem cells (MSC) were demonstrated to enhance sphincter healing after injury and primary repair in a rat preclinical model. In the present article we investigated whether unexpanded BM mononuclear cells (MNC) may also be effective.

Methods: Thirty-two rats, divided into groups, underwent sphincterotomy and repair (SR) with primary suture of anal sphincters plus intrasphincteric injection of saline (CTR), or of in-vitro expanded MSC, or of minimally manipulated MNC; moreover, the fourth group underwent sham operation. At day 30, histologic, morphometric, in-vitro contractility, and functional analysis were performed.

Results: Treatment with both MSC and MNC improved muscle regeneration and increased contractile function of anal sphincters after SR compared with CTR (p < 0.05). No significant difference was observed between the two BM stem cell types used. GFP-positive cells (MSC and MNC) remained in the proximity of the lesion site up to 30 days post injection.

Conclusions: In the present study we demonstrated in a preclinical model that minimally manipulated BM-MNC were as effective as in-vitro expanded MSC for the recovery of anal sphincter injury followed by primary sphincter repair. These results may serve as a basis for improving clinical applications of stem cell therapy in human anal incontinence treatment.

Keywords: Anal incontinence; Anal sphincter injury; Anal sphincter repair; Bone marrow mesenchymal stem cells; Bone marrow mononuclear cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anal Canal / injuries
  • Anal Canal / surgery*
  • Animals
  • Bone Marrow Cells / cytology*
  • Bone Marrow Cells / physiology
  • Disease Models, Animal
  • Fecal Incontinence / physiopathology
  • Fecal Incontinence / therapy*
  • Genes, Reporter
  • Humans
  • Leukocytes, Mononuclear / cytology*
  • Leukocytes, Mononuclear / physiology
  • Leukocytes, Mononuclear / transplantation
  • Male
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / physiology
  • Muscle Contraction / physiology
  • Rats
  • Rats, Inbred Lew
  • Regeneration / physiology
  • Sphincterotomy, Endoscopic