Abstract
The present study demonstrates that acute ozone exposure of healthy human subjects enhances lung immune responses to subsequent bacterial stimuli. This highlights common air pollutant exposures as modifiers of the intensity of pulmonary immune activation.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Inhalation
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Adult
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Animals
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Female
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Healthy Volunteers
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Humans
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Immunity, Innate / drug effects*
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Immunity, Innate / genetics
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Immunity, Innate / physiology
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In Vitro Techniques
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Lipopolysaccharide Receptors / genetics
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Lipopolysaccharides / pharmacology
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Macrophages, Alveolar / drug effects*
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Macrophages, Alveolar / immunology*
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Macrophages, Alveolar / metabolism
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Male
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Mice
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Ozone / administration & dosage
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Ozone / pharmacology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Tetradecanoylphorbol Acetate / pharmacology
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Toll-Like Receptor 4 / genetics
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Young Adult
Substances
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Lipopolysaccharide Receptors
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Lipopolysaccharides
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RNA, Messenger
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TLR4 protein, human
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Toll-Like Receptor 4
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Ozone
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Tetradecanoylphorbol Acetate